POS1407 COMPARISON OF CAROTID SUBCLINICAL ATHEROSCLEROSIS AND STRUCTURAL DAMAGE IN AXIAL SPONDYLITIS WITH AND WITHOUT CONCOMITANT INFLAMMATORY BOWEL DISEASE. A MULTICENTER STUDY WITH 886 PATIENTS. . A MULTICENTER STUDY WITH 886 PATIENTS

Background: The prevalence of inflammatory bowel disease (IBD) in ankylosing spondylitis (AS) has been reported to range between 6%-15%. As occurs with axial spondyloarthrtitis (axSpA), patients IBD have an increased risk cardiovascular (CV) events because a process accelerated atherosclerosis 1 . However, it is unknown whether the presence confers CV axSpA. Objectives: To compare atherosclerotic burden, events, factors and related including structural damage axSpA without IBD. Methods: Cross-sectional analysis AtheSpAin cohort, Spanish multicenter cohort designed for study axSpA, comparing concomitant Background information on disease-related was reviewed. Data status at time were also obtained, assessed by syndesmophytes, severity sacroiliitis (defined as grade 3 or 4 according New York criteria), modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS). Carotid ultrasound (US) performed all study, measurement carotid intima-media wall thickness (cIMT) plaque detection Mannhein consensus criteria. Results: A set 886 included. 829 (93.6%) them had no IBD, which present 57 (6.4%) patients. Age, sex AS/nr-axSpA ratio comparable both groups (Table 1. next page). Patients characterised lower HLA B27 (46% vs 72%, p=0.01) higher psoriasis (21% 10%, Regarding peripheral (history synovitis, enthesitis, dactylitis) hip involvement, differences found groups. There either With respect management disease, prednisone 13%, p = 0.03), DMARDs (54% 35%, 0.01) anti-TNF? therapy 31%, 0.00) more commonly used group while treatment NSAIDs frequent (81% 70%, 0.04). features, smoking (34% 21%, 0.045) No observed neither lipid profile blood pressure nor (5% 4%, p=0.99) 1) subclinical atherogenic burden plaques (31% 37%, p=0.45) cIMT (645 ± 147 mm 636 112 mm, 0.64) Conclusion: does not confer additional In our series, showed frequency psoriasis. Table (n=829 ) (n=57 Men/Women, n 272/557 15/42 0.33 Mean age (years) ±SD 49 13 10 0.99 AS/nr-AxSpa 656/173 45/12 0.97 History Current smoker 285 (34) 12 (21) 0.045 Obesitty Dyslipemia 280 16 (28) 0.42 Hypertension 223 (27) 0.79 Diabetes Mellitus 60 (7) Chronic Kidney Disease 20 (2) 2 (4) 0.65 (% 40 (5) Structural Presence (%) 307 (37%) 23 (49%) 0.66 mSASSS 5 (1-15) 6 (3-23) 0.64 Severe (grade 3,4), 436 (53) 34 (60) data 261 (31) 21 (37) 0.45 IMT (mm) 645 >= 0.9 46 (6) 0 (0) 0.066 Abbreviations: AS spondylitis. AxSpA= cardiovascular. Inflammatory disease. thickness. Nr-axSpA no-radiographic Disclosure Interests: None declared